Mice, Hamsters and macaques were immunized with a single dose of ChAd-SARS-CoV-2-S conferred superior protection against SARS-CoV-2 challenge. Post-challenge with SARS-CoV-2, viral clearance was observed in both lower and upper airways in all these animal models.
Thus, intranasal immunization of ChAd-SARS-CoV-2-S can create an immune response in the nose, which is the point of entry for the virus—thereby protecting against disease, infection, and transmission. Please find more information on the Hamster, Mice and Rhesus macaques studies
*Disclaimer: The provided study information is a preprint publish and has not yet undergone peer review. The findings are provisional, and the conclusions/final results may differ.
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