Protective Efficacy of candidate vaccine ChAd-SARS-CoV-2-S demonstrated in Mice and Hamsters:
Mice and Hamsters immunized with a single dose of ChAd-SARS-CoV-2-S conferred superior protection against SARS-CoV-2 challenge, more so than one or two intramuscular immunizations of the same vaccine and dose. Post-challenge with SARS-CoV-2, viral clearance was observed in both lower and upper airways.
Thus, intranasal immunization of ChAd-SARS-CoV-2-S can create an immune response in the nose, which is the point of entry for the virus—thereby protecting against disease, infection, and transmission.
For more information on the study: https://www.biorxiv.org/content/10.1101/2020.12.02.408823v1
*Disclaimer: The provided study information is a preprint publish and has not yet undergone peer review. The findings are provisional, and the conclusions/final results may differ.
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